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现在位置:首页 > 医学版 > 期刊论文 > 药学 > 分子药理学杂志 > 2005年
2005年 
第1期
 
    06-11-03 Alternative Promoters Determine Tissue-Specific Expression Profiles of the Human Microsomal Epoxide Hydrolase Gene (EPHX1)
    06-11-03 Agonists at Opioid Receptors Spin the Wheels to Keep the Action Going
    06-11-03 The Protein Kinase C Inhibitor Go6976 [12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] Pote
    06-11-03 H3 Autoreceptors Modulate Histamine Synthesis through Calcium/Calmodulin- and cAMP-Dependent Protein Kinase Pathways
    06-11-03 Protein Kinase C-Independent Effects of Protein Kinase D3 in Glucose Transport in L6 Myotubes
    06-11-03 Dynamics of Ca2+-Dependent Cl- Channel Modulation by Niflumic Acid in Rabbit Coronary Arterial Myocytes
    06-11-03 Down-Regulation Does Not Mediate Natriuretic Peptide-Dependent Desensitization of Natriuretic Peptide Receptor (NPR)-A or NPR-B: Guanylyl Cy
    06-11-03 Structural Basis for Epibatidine Selectivity at Desensitized Nicotinic Receptors
    06-11-03 Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by o
    06-11-03 Amphetamines Take Two to Tango: an Oligomer-Based Counter-Transport Model of Neurotransmitter Transport Explores the Amphetamine Action
    06-11-03 Interaction between Cardiac Calsequestrin and Drugs with Known Cardiotoxicity
    06-11-03 Estrogen Receptor Activation of Phosphoinositide-3 Kinase, Akt, and Nitric Oxide Signaling in Cerebral Blood Vessels: Rapid and Long-Term Ef
    06-11-03 Regulation of P2Y1 Receptor-Mediated Signaling by the Ectonucleoside Triphosphate Diphosphohydrolase Isozymes NTPDase1 and NTPDase2
    06-11-03 Multiple Independent Functions of Arrestins in the Regulation of Protease-Activated Receptor-2 Signaling and Trafficking
    06-11-03 The Cardiovascular Actions of Protease-Activated Receptors

第2期
 
    06-11-03 Negative Regulation of TRPC3 Channels by Protein Kinase C-Mediated Phosphorylation of Serine 712
    06-11-03 Isoform-Specific Regulation of Adenylyl Cyclase Function by Disruption of Membrane Trafficking
    06-11-03 Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumo
    06-11-03 Membrane Structure Modulation, Protein Kinase C Activation, and Anticancer Activity of Minerval
    06-11-03 Steroidogenic Factor-1 Interacts with cAMP Response Element-Binding Protein to Mediate cAMP Stimulation of CYP1B1 via a Far Upstream Enhance
    06-11-03 Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding
    06-11-03 Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
    06-11-03 Picrotoxin Accelerates Relaxation of GABAC Receptors
    06-11-03 Kv2.1 Channel Activation and Inactivation Is Influenced by Physical Interactions of Both Syntaxin 1A and the Syntaxin 1A/Soluble N-Ethylmale
    06-11-03 Receptor-Independent Activation of GABAergic Neurotransmission and Receptor-Dependent Nontranscriptional Activation of Phosphatidylinositol
    06-11-03 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Insulin-Like Growth Factor Binding Protein-1 Gene Expression and Counteracts the Negative Effect
    06-11-03 Characterization of Binding of Folates and Antifolates to Brush-Border Membrane Vesicles Isolated from Human Kidney
    06-11-03 Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers
    06-11-03 Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells
    06-11-03 The mGluR5 Antagonist 6-Methyl-2-(phenylethynyl)pyridine Decreases Ethanol Consumption via a Protein Kinase C-Dependent Mechanism

第3期
 
    06-11-03 Activators of Cation Channels: Potential in Treatment of Channelopathies
    06-11-03 The Nongenotropic Synthetic Ligand 4-Estren-317-diol Is a High-Affinity Genotropic Androgen Receptor Agonist
    06-11-03 A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator
    06-11-03 Macrophage Inflammatory Protein 2 Inhibits -Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Act
    06-11-03 The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse
    06-11-03 Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties
    06-11-03 PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2
    06-11-03 Constitutive Expression of Peroxisome Proliferator-Activated Receptor -Regulated Genes in Dwarf Mice
    06-11-03 Functional Characterization of Go Signaling through G Protein-Regulated Inducer of Neurite Outgrowth 1
    06-11-03 Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
    06-11-03 Role of the C Terminus in Neuropeptide Y Y Receptor Desensitization and Internalization
    06-11-03 Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Mo
    06-11-03 Urinary Trypsin Inhibitor Protects against Systemic Inflammation Induced by Lipopolysaccharide
    06-11-03 Structural Determinants of Arylacetic Acid Nonsteroidal Anti-Inflammatory Drugs Necessary for Binding and Activation of the Prostaglandin D2
    06-11-03 An Orphan Receptor Adopted by a Family of Transmitters

第4期
 
    06-11-03 Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives
    06-11-03 Cotreatment with Suberanoylanilide Hydroxamic Acid and 17-Allylamino 17-demethoxygeldanamycin Synergistically Induces Apoptosis in Bcr-Abl+
    06-11-03 N-Methyl-D-aspartate and Brain-Derived Neurotrophic Factor Induce Distinct Profiles of Extracellular Signal-Regulated Kinase, Mitogen- and S
    06-11-03 Molecular Interactions between Matrilysin and the Matrix Metalloproteinase Inhibitor Doxycycline Investigated by Deuterium Exchange Mass Spe
    06-11-03 A Novel Class of Fusion Polypeptides Inhibits Exocytosis
    06-11-03 Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes
    06-11-03 The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine2B Receptor Is a Gain of Proliferative Functions
    06-11-03 TRPV1b, a Functional Human Vanilloid Receptor Splice Variant
    06-11-03 Glycosaminoglycans and Protein Disulfide Isomerase-Mediated Reduction of HIV Env
    06-11-03 Extracellular Loop 3 (EL3) and EL3-Proximal Transmembrane Helix 7 of the Mammalian Type I and Type II Gonadotropin-Releasing Hormone (GnRH)
    06-11-03 Molecular Determinants of the Agonist Binding Domain of a P2X Receptor Channel
    06-11-03 Phosphatidylinositol-4,5-bisphosphate: Actin Dynamics and the Regulation of ATP-Dependent and -Independent Secretion
    06-11-03 Fusion Polypeptides That Inhibit Exocytosis: Fusing Aptamer and Cell-Penetrating Peptide Technologies and Pharmacologies
    06-11-03 Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Antico
    06-11-03 Molecular Determinants of Substrate/Inhibitor Binding to the Human and Rabbit Renal Organic Cation Transporters hOCT2 and rbOCT2

第5期
 
    06-11-03 Heparan Sulfate Regulates the Antiangiogenic Activity of Endothelial Monocyte-Activating Polypeptide-II at Acidic pH
    06-11-03 A Synthetic Derivative of the Natural Product Rocaglaol Is a Potent Inhibitor of Cytokine-Mediated Signaling and Shows Neuroprotective Activ
    06-11-03 Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid
    06-11-03 Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels
    06-11-03 Isoflurane Induces a Protein Kinase C -Dependent Increase in Cell-Surface Protein Level and Activity of Glutamate Transporter Type 3
    06-11-03 From Plants to Man: The GPCR "Tree of Life"
    06-11-03 -Adrenergic Receptor Stimulation Promotes Gs Internalization through Lipid Rafts: A Study in Living Cells
    06-11-03 Investigations of Calsequestrin as a Target for Anthracyclines: Comparison of Functional Effects of Daunorubicin, Daunorubicinol, and Triflu
    06-11-03 Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4'-Trimethoxystilbene
    06-11-03 Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-D-aspartate Receptors Determined by Site-Directed Mutagen
    06-11-03 Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase
    06-11-03 Palmitoylation of the 5-Hydroxytryptamine4a Receptor Regulates Receptor Phosphorylation, Desensitization, and -Arrestin-Mediated Endocytosis
    06-11-03 Blockade of Vascular Endothelial Growth Factor Receptor Signal Pathway and Antitumor Activity of ON-III (2',4'-Dihydroxy-6'-methoxy-3',5'-di
    06-11-03 Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for
    06-11-03 Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3 Inhibition, and Viral R

第6期
 
    06-11-03 Neurotensin Stimulates Interleukin-8 Expression through Modulation of IB Phosphorylation and p65 Transcriptional Activity: Involvement of Pr
    06-11-03 Centaurin-1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits 2-Adrenoceptor Internalization
    06-11-03 Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronid
    06-11-03 Mutation of the DRY Motif Reveals Different Structural Requirements for the CC Chemokine Receptor 5-Mediated Signaling and Receptor Endocyto
    06-11-03 The Effects of Subunit Composition on the Inhibition of Nicotinic Receptors by the Amphipathic Blocker 2,2,6,6-Tetramethylpiperidin-4-yl Hep
    06-11-03 Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-1 El
    06-11-03 Retinoids Potentiate Peroxisome Proliferator-Activated Receptor Action in Differentiation, Gene Expression, and Lipid Metabolic Processes i
    06-11-03 Functional Interactions Between Nucleotide Binding Domains and Leukotriene C4 Binding Sites of Multidrug Resistance Protein 1 (ABCC1)
    06-11-03 Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive
    06-11-03 Endoplasmic Reticulum Stress Links Dyslipidemia to Inhibition of Proteasome Activity and Glucose Transport by HIV Protease Inhibitors
    06-11-03 Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gen
    06-11-03 Differential Spatial Approximation between Cholecystokinin Residue 30 and Receptor Residues in Active and Inactive Conformations
    06-11-03 Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the Interaction of Synaptophysin I with VAMP2
    06-11-03 What's for Lunch at the Conformational Cafeteria
    06-11-03 The Neurotransmitter Noradrenaline Rescues Septal Cholinergic Neurons in Culture from Degeneration Caused by Low-Level Oxidative Stress

第7期
 
    06-11-03 Influence of the Membrane Lipid Structure on Signal Processing via G Protein-Coupled Receptors
    06-11-03 Distinct Structural Features of Phospholipids Differentially Determine Ethanol Sensitivity and Basal Function of BK Channels
    06-11-03 Nanomolar and Micromolar Effects of 15-Deoxy-12,14-prostaglandin J2 on Amnion-Derived WISH Epithelial Cells: Differential Roles of Peroxisom
    06-11-03 In the Rostral Ventrolateral Medulla, the 70-kDa Heat Shock Protein (HSP70), but Not HSP90, Confers Neuroprotection against Fatal Endotoxemi
    06-11-03 Possible Involvement of CPI-17 in Augmented Bronchial Smooth Muscle Contraction in Antigen-Induced Airway Hyper-Responsive Rats
    06-11-03 GABAA Receptor-Associated Protein Regulates GABAA Receptor Cell-Surface Number in Xenopus laevis Oocytes
    06-11-03 Analysis of the In Vivo Functions of Mrp3
    06-11-03 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid and Related Compounds Inhibit Growth of Colon Cancer Cells through Peroxisome Proliferator-Acti
    06-11-03 Ric-8 Enhances G Protein -Dependent Signaling in Response to -Binding Peptides in Intact Cells
    06-11-03 The RXR-Type Endoplasmic Reticulum-Retention/Retrieval Signal of GABAB1 Requires Distant Spacing from the Membrane to Function
    06-11-03 Inhibition of T-Type Calcium Channels Protects Neurons from Delayed Ischemia-Induced Damage
    06-11-03 Receptor Signaling and Endocytosis Are Differentially Regulated by Somatostatin Analogs
    06-11-03 Akt Is Essential for Insulin Modulation of Amphetamine-Induced Human Dopamine Transporter Cell-Surface Redistribution
    06-11-03 Cellular and Pharmacogenetics Foundation of Synergistic Interaction of Pemetrexed and Gemcitabine in Human NoneCSmall-Cell Lung Cancer Cells
    06-11-03 Cysteine 2.59(89) in the Second Transmembrane Domain of Human CB2 Receptor Is Accessible within the Ligand Binding Crevice: Evidence for Pos

第8期
 
    06-11-03 Orphanin FQ/Nociceptin Potentiates [D-Ala2,N-Me-Phe4,Gly5-ol]-EnkephalineCInduced eOpioid Receptor Phosphorylation
    06-11-03 Single Nucleotide Polymorphisms in the Human Norepinephrine Transporter Gene Affect Expression, Trafficking, Antidepressant Interaction, and
    06-11-03 Down-Regulation of Na+/Ca2+ Exchanger by Fluvastatin in Rat Cardiomyoblast H9c2 Cells: Involvement of RhoB in Na+/Ca2+ Exchanger mRNA Stabil
    06-11-03 cAMP and Extracellular Signal-Regulated Kinase Signaling in Response to D-Amphetamine and Methylphenidate in the Prefrontal Cortex in Vivo:
    06-11-03 How the Monoamine Transporter Garden Grows
    06-11-03 Expression Profiling of ABC Transporters in a Drug-Resistant Breast Cancer Cell Line Using AmpArray
    06-11-03 Identification of Indole Derivatives Exclusively Interfering with a G Protein-Independent Signaling Pathway of the Prostaglandin D2 Receptor
    06-11-03 A Pregnane X Receptor Agonist with Unique Species-Dependent Stereoselectivity and Its Implications in Drug Development
    06-11-03 Spatial Orientation of the Antagonist Granisetron in the Ligand-Binding Site of the 5-HT3 Receptor
    06-11-03 Chemotherapy Compounds in Cervical Cancer Cells Primed by Reconstitution of p53 Function after Short Interfering RNA-Mediated Degradation of
    06-11-03 Discovery of Novel Flavin-Containing Monooxygenase 3 (FMO3) Single Nucleotide Polymorphisms and Functional Analysis of Upstream Haplotype Va
    06-11-03 Arsenite-Induced Aryl Hydrocarbon Receptor Nuclear Translocation Results in Additive Induction of Phase I Genes and Synergistic Induction of
    06-11-03 Single Mutations at Asn295 and Leu305 in the Cytoplasmic Half of Transmembrane -Helix Domain 7 of the AT1 Receptor Induce Promiscuous Agonis
    06-11-03 Agonist-Induced Interactions between Angiotensin AT1 and Epidermal Growth Factor Receptors
    06-11-03 The Coordination of Prostaglandin E2 Production by Sphingosine-1-phosphate and Ceramide-1-phosphate

第9期
 
    06-11-03 Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid R
    06-11-03 Mechanism of Inhibition of TRPC Cation Channels by 2-Aminoethoxydiphenylborane
    06-11-03 The Long and Short of Vascular Smooth Muscle Phosphodiesterase-4 As a Putative Therapeutic Target
    06-11-03 Poly(C) Binding Protein Family Is a Transcription Factor in e?Opioid Receptor Gene Expression
    06-11-03 The Role of Protein Synthesis and Degradation in the Post-Transcriptional Regulation of Rat Multidrug Resistance-Associated Protein 2 (Mrp2,
    06-11-03 A Rapid New Assay to Detect RNA Editing Reveals Antipsychotic-Induced Changes in Serotonin-2C Transcripts
    06-11-03 Guanine Nucleotide Exchange-Independent Activation of Gs Protein by 2-Adrenoceptor
    06-11-03 Thromboxane A2 Promotes Interleukin-6 Biosynthesis Mediated by an Activation of Cyclic AMP-Response Element-Binding Protein in 1321N1 Human
    06-11-03 Capsaicin Regulates Voltage-Dependent Sodium Channels by Altering Lipid Bilayer Elasticity
    06-11-03 HIV Protease Inhibitors Activate the Unfolded Protein Response in Macrophages: Implication for Atherosclerosis and Cardiovascular Disease
    06-11-03 CYP2C9 Genotype-Dependent Effects on in Vitro Drug-Drug Interactions: Switching of Benzbromarone Effect from Inhibition to Activation in the
    06-11-03 The Role of Thr139 in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Sensitivity to (+)-Calanolide A
    06-11-03 Enhanced CCAAT/Enhancer-Binding Protein -Liver-Enriched Inhibitory Protein Production by Oltipraz, Which Accompanies CUG Repeat-Binding Prot
    06-11-03 Down-Regulation of DNA Topoisomerase II Leads to Prolonged Cell Cycle Transit in G2 and Early M Phases and Increased Survival to Microtubule
    06-11-03 Can a GDP-Liganded G-Protein Be Active

第10期
 
    06-11-03 Morphine-Induced e?Opioid Receptor Desensitization
    06-11-03 Mechanism of the Insulin-Releasing Action of -Ketoisocaproate and Related -Keto Acid Anions
    06-11-03 Sialylation of Human Thyrotropin Receptor Improves and Prolongs Its Cell-Surface Expression
    06-11-03 Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway
    06-11-03 Activation of Mitogen-Activated Protein Kinases by Peroxisome Proliferator-Activated Receptor Ligands: An Example of Nongenomic Signaling
    06-11-03 Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt
    06-11-03 Overexpression of Rad23 Confers Resistance to Methylmercury in Saccharomyces cerevisiae via Inhibition of the Degradation of Ubiquitinated P
    06-11-03 Interaction of Bivalent Ligand KDN21 with Heterodimeric - Opioid Receptors in Human Embryonic Kidney 293 Cells
    06-11-03 Differential Activation of Adenylate Cyclase and Receptor Internalization by Novel Dopamine D1 Receptor Agonists
    06-11-03 N-Methyl-N'-nitro-N-nitrosoguanidine Activates Cell-Cycle Arrest through Distinct Mechanisms Activated in a Dose-Dependent Manner
    06-11-03 Human Hepatobiliary Transport of Organic Anions Analyzed by Quadruple-Transfected Cells
    06-11-03 Structural Basis for Competition between Drug Binding and Kv1.3 Accessory Subunit-Induced N-Type Inactivation of Kv1.5 Channels
    06-11-03 Nitric Oxide Donors Induce Neurotrophin-Like Survival Signaling and Protect Neurons against Apoptosis
    06-11-03 Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids
    06-11-03 Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review